Calcium promotes membrane association of reticulocyte 15-lipoxygenase

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Calcium promotes membrane association of reticulocyte 15-lipoxygenase.

The reticulocyte 15-lipoxygenase (linoleate:oxygen oxidoreductase, EC 1.13.11.12) is implicated in oxidative damage to reticulocyte mitochondria before their elimination by degradation during maturation to the erythrocyte. A proportion of the 15-lipoxygenase sediments with the mitochondrial-rich stromal fraction of density-gradient-fractionated rabbit reticulocytes suggesting a physical associa...

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Reticulocyte 15-lipoxygenase-I is important in acetylcholine-induced endothelium-dependent vasorelaxation in rabbit aorta.

OBJECTIVE Aortic 15-lipoxygenase (15-LO) metabolizes arachidonic acid (AA) to 15-hydroperoxyeicosatetraenoic acid, which is then converted to the vasodilators 15-hydroxy-11,12-epoxyeicosatrienoic acid and 11,12,15-trihydroxyeicosatrienoic acid. These metabolites contribute to endothelium-dependent relaxations of rabbit aorta to AA and acetylcholine. We investigated the identity of rabbit aortic...

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DDX6 recruits translational silenced human reticulocyte 15-lipoxygenase mRNA to RNP granules.

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ALOX 15 ( arachidonate 15 - lipoxygenase )

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1994

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj2980377